A1 Refereed original research article in a scientific journal
Genetic and observational evidence: No independent role for cholesterol efflux over static high-density lipoprotein concentration measures in coronary heart disease risk assessment
Authors: Kuusisto Sanna, Karjalainen Minna K., Tillin Therese, Kangas Antti J., Holmes Michael V., Kähönen Mika, Lehtimäki Terho, Viikari Jorma, Perola Markus, Chaturvedi Nishi, Salomaa Veikko, Raitakari Olli T., Järvelin Marjo-Riitta, Kettunen Johannes, Ala-Korpela Mika
Publisher: WILEY
Publication year: 2022
Journal: Journal of Internal Medicine
Journal name in source: JOURNAL OF INTERNAL MEDICINE
Journal acronym: J INTERN MED
Number of pages: 8
ISSN: 0954-6820
eISSN: 1365-2796
DOI: https://doi.org/10.1111/joim.13479
Web address : https://onlinelibrary.wiley.com/doi/10.1111/joim.13479
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/174993580
Background
Observational findings for high-density lipoprotein (HDL)-mediated cholesterol efflux capacity (HDL-CEC) and coronary heart disease (CHD) appear inconsistent, and knowledge of the genetic architecture of HDL-CEC is limited.
Objectives
A large-scale observational study on the associations of HDL-CEC and other HDL-related measures with CHD and the largest genome-wide association study (GWAS) of HDL-CEC.
Participants/methods
Six independent cohorts were included with follow-up data for 14,438 participants to investigate the associations of HDL-related measures with incident CHD (1,570 events). The GWAS of HDL-CEC was carried out in 20,372 participants.
Results
HDL-CEC did not associate with CHD when adjusted for traditional risk factors and HDL cholesterol (HDL-C). In contradiction, almost all HDL-related concentration measures associated consistently with CHD after corresponding adjustments. There were no genetic loci associated with HDL-CEC independent of HDL-C and triglycerides.
Conclusion
HDL-CEC is not unequivocally associated with CHD in contrast to HDL-C, apolipoprotein A-I, and most of the HDL subclass particle concentrations.
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