Applications of PET in diabetes research



: Nuutila P

: 1997

: Hormone and Metabolic Research

: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

: Horm Metab Res

: 29

: 7

: 337

: 9

: 0018-5043

DOI: https://doi.org/10.1055/s-2007-979048


Use of positron emission tomography (PET) combined with 18F-fluoro-2-deoxy-D-glucose (18FDG) allows a noninvasive quantitation of glucose uptake in individual tissues such as human muscles and heart. Using 15O-labelled water and 18FDG the role of blood flow as a regulator of glucose metabolism can be studied with PET. PET has allowed study of the factors regulating heart glucose uptake in normal subjects and in subjects with alterations in skeletal muscle insulin sensitivity, and has provided evidence that insulin stimulated rates of blood flow and glucose uptake do not co-localize within muscle tissues.



Last updated on 2024-26-11 at 20:52