A2 Refereed review article in a scientific journal
Applications of PET in diabetes research
Authors: Nuutila P
Publication year: 1997
Journal: Hormone and Metabolic Research
Journal name in source: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Journal acronym: Horm Metab Res
Volume: 29
Issue: 7
First page : 337
Last page: 9
ISSN: 0018-5043
DOI: https://doi.org/10.1055/s-2007-979048
Abstract
Use of positron emission tomography (PET) combined with 18F-fluoro-2-deoxy-D-glucose (18FDG) allows a noninvasive quantitation of glucose uptake in individual tissues such as human muscles and heart. Using 15O-labelled water and 18FDG the role of blood flow as a regulator of glucose metabolism can be studied with PET. PET has allowed study of the factors regulating heart glucose uptake in normal subjects and in subjects with alterations in skeletal muscle insulin sensitivity, and has provided evidence that insulin stimulated rates of blood flow and glucose uptake do not co-localize within muscle tissues.
Use of positron emission tomography (PET) combined with 18F-fluoro-2-deoxy-D-glucose (18FDG) allows a noninvasive quantitation of glucose uptake in individual tissues such as human muscles and heart. Using 15O-labelled water and 18FDG the role of blood flow as a regulator of glucose metabolism can be studied with PET. PET has allowed study of the factors regulating heart glucose uptake in normal subjects and in subjects with alterations in skeletal muscle insulin sensitivity, and has provided evidence that insulin stimulated rates of blood flow and glucose uptake do not co-localize within muscle tissues.
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