A1 Refereed original research article in a scientific journal

Maternal HPV-antibodies and seroconversion to HPV in children during the first 3 years of life




AuthorsSyrjänen Stina, Waterboer Tim, Rintala Marjut, Pawlita Michael, Syrjänen Kari, Louvanto Karolina, Grenman Seija

PublisherNATURE PORTFOLIO

Publication year2022

JournalScientific Reports

Journal name in sourceSCIENTIFIC REPORTS

Journal acronymSCI REP-UK

Article number 2227

Volume12

Number of pages11

ISSN2045-2322

eISSN2045-2322

DOIhttps://doi.org/10.1038/s41598-022-06343-z(external)

Web address https://www.nature.com/articles/s41598-022-06343-z(external)

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/174960190(external)


Abstract

To assess the dynamics of human papillomavirus (HPV) serology, we analyzed HPV6-,11-,16-,18-, and 45 antibodies in infants during the first 36 months of their life. Serial serum samples of 276/327 mother-child pairs were collected at baseline (mothers) and at months 1, 2, 6, 12, 24 and 36 (offspring), and tested for HPVL1-antibodies using the GST-L1 assay. Concordance between maternal and infant HPV-antibody levels remained high until month-6 (p < = 0.001), indicating maternal antibody transfer. At 1 month, 40-62% of the infants tested seropositive to any of the 5 HPV-types. Between 1-3 years of age, 53% (58/109) of the children born to HPV-seronegative mothers tested HPV-seropositive. Times to positive seroconversion varied between13.4 and 18.7 months, and times to negative seroconversion (decay) between 8.5 and 9.9 months. Significant independent predictors of infants' seroconversion to LR-HPV were hand warts and mother's history of oral warts and seroconversion to LR-HPV. No predictors of seroconversion to HR-HPV were identified. Maternal HPV-IgG-antibodies are transferred to her offspring and remain detectable for 6 months, corroborating the IgG molecule's half-life. Seroconversion to HPV-genotypes 6, 11, 16 and 18 was confirmed among children born to HPV-seronegative mothers, implicating an immune response to these HPV-genotypes during early infancy.


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Last updated on 2024-26-11 at 21:45