A2 Refereed review article in a scientific journal
PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity
Authors: Khan Mohd Moin, Kalim Ubaid Ullah, Khan Meraj H, Lahesmaa Riitta
Publisher: FRONTIERS MEDIA SA
Publication year: 2022
Journal: Frontiers in Immunology
Journal name in source: FRONTIERS IN IMMUNOLOGY
Journal acronym: FRONT IMMUNOL
Article number: 786857
Volume: 12
Number of pages: 9
ISSN: 1664-3224
eISSN: 1664-3224
DOI: https://doi.org/10.3389/fimmu.2021.786857
Web address : https://doi.org/10.3389/fimmu.2021.786857
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/174926668
Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric Ser/Thr phosphatase that regulates many cellular processes. The role of PP2A as a tumor suppressor has been extensively studied and reviewed. However, emerging evidence suggests PP2A constrains inflammatory responses and is important in autoimmune and neuroinflammatory diseases. Here, we reviewed the existing literature on the role of PP2A in T-cell differentiation and autoimmunity. We have also discussed the modulation of PP2A activity by endogenous inhibitors and its small-molecule activators as potential therapeutic approaches against autoimmunity.
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