A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity
Tekijät: Khan Mohd Moin, Kalim Ubaid Ullah, Khan Meraj H, Lahesmaa Riitta
Kustantaja: FRONTIERS MEDIA SA
Julkaisuvuosi: 2022
Journal: Frontiers in Immunology
Tietokannassa oleva lehden nimi: FRONTIERS IN IMMUNOLOGY
Lehden akronyymi: FRONT IMMUNOL
Artikkelin numero: 786857
Vuosikerta: 12
Sivujen määrä: 9
ISSN: 1664-3224
eISSN: 1664-3224
DOI: https://doi.org/10.3389/fimmu.2021.786857
Verkko-osoite: https://doi.org/10.3389/fimmu.2021.786857
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/174926668
Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric Ser/Thr phosphatase that regulates many cellular processes. The role of PP2A as a tumor suppressor has been extensively studied and reviewed. However, emerging evidence suggests PP2A constrains inflammatory responses and is important in autoimmune and neuroinflammatory diseases. Here, we reviewed the existing literature on the role of PP2A in T-cell differentiation and autoimmunity. We have also discussed the modulation of PP2A activity by endogenous inhibitors and its small-molecule activators as potential therapeutic approaches against autoimmunity.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
