A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Sinonasal inverted papilloma: malignant transformation and non-sinonasal malignancies




TekijätViitasalo Sanna, Ilmarinen Taru, Aaltonen Leena-Maija, Hagström Jaana, Hytönen Maija, Hammarén-Malmi Sari, Pietarinen Petra, Järvenpää Pia, Kinnari Teemu, Geneid Ahmed, Lilja Markus

KustantajaWiley

Julkaisuvuosi2023

JournalLaryngoscope

Tietokannassa oleva lehden nimiLARYNGOSCOPE

Lehden akronyymiLARYNGOSCOPE

Vuosikerta133

Numero3

Aloitussivu506

Lopetussivu511

Sivujen määrä6

ISSN0023-852X

DOIhttps://doi.org/10.1002/lary.30128

Verkko-osoite https://doi.org/10.1002/lary.30128

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/174906537


Tiivistelmä

Objectives: To assess malignant transformation rate, non-sinonasal malignancies, and factors contributing to recurrence in patients treated for sinonasal inverted papilloma (SNIP).

Study design: Retrospective study.

Methods: We retrospectively reviewed medical records of all patients treated for SNIP (n = 296) between the years 1984-2014 at Helsinki University Hospital. Data from the Finnish Cancer Registry confirmed the number of those patients with sinonasal and non-sinonasal malignancies.

Results: Only 2 of 296 (0.7%) patients primarily diagnosed with benign SNIP developed sinonasal cancer in a mean follow-up of 5.8 years. The most common non-sinonasal cancer sites were similar to those reported for the whole Finnish population. None of the patients presented with an HPV-associated non-sinonasal malignancy. The recurrence rate among patients who underwent attachment-oriented surgery was significantly lower compared to those operated on with other approaches (40.2% vs. 56.6%, p = 0.006). Dysplasia in SNIP was associated with a higher recurrence rate (p < 0.001).

Conclusions: Malignant transformation of SNIP was rare. Patients with SNIP were not prone to HPV-associated non-sinonasal malignancies. Endoscopic resection and attachment-oriented surgery have become predominant approaches in the treatment of SNIP; meanwhile, the total number of SNIP recurrences has decreased.


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Last updated on 2024-26-11 at 15:30