A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Relationships between global functioning and neuropsychological predictors in subjects at high risk of psychosis or with a recent onset of depression
Tekijät: Squarcina Letizia, Kambeitz-Ilankovic Lana, Bonivento Carolina, Prunas Cecilia, Oldani Lucio, Wenzel Julian, Ruef Anne, Dwyer Dominic, Ferro Adele, Borgwardt Stefan, Kambeitz Joseph, Lichtenstein Theresa Katharina, Meisenzahl Eva, Pantelis Christos, Rosen Marlene, Upthegrove Rachel, Antonucci Linda A, Bertolino Alessandro, Lencer Rebekka, Ruhrmann Stephan, Salokangas Raimo RK, Schultze-Lutter Frauke, Chisholm Katharine, Stainton Alexandra, Wood Stephen J, Koutsouleris Nikolaos, Brambilla Paolo
Kustantaja: TAYLOR & FRANCIS LTD
Julkaisuvuosi: 2022
Journal: World Journal of Biological Psychiatry
Tietokannassa oleva lehden nimi: WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
Lehden akronyymi: WORLD J BIOL PSYCHIA
Vuosikerta: 23
Numero: 8
Aloitussivu: 573
Lopetussivu: 581
Sivujen määrä: 9
ISSN: 1562-2975
eISSN: 1562-2975
DOI: https://doi.org/10.1080/15622975.2021.2014955
Verkko-osoite: https://www.tandfonline.com/doi/full/10.1080/15622975.2021.2014955
Objective
Psychotic disorders are frequently associated with decline in functioning and cognitive difficulties are observed in subjects at clinical high risk (CHR) for psychosis. In this work, we applied automatic approaches to neurocognitive and functioning measures, with the aim of investigating the link between global, social and occupational functioning, and cognition.
Methods
102 CHR subjects and 110 patients with recent onset depression (ROD) were recruited. Global assessment of functioning (GAF) related to symptoms (GAF-S) and disability (GAF-D). and global functioning social (GF-S) and role (GF-R), at baseline and of the previous month and year, and a set of neurocognitive measures, were used for classification and regression.
Results
Neurocognitive measures related to GF-R at baseline (r = 0.20, p = 0.004), GF-S at present (r = 0.14, p = 0.042) and of the past year (r = 0.19, p = 0.005), for GAF-F of the past month (r = 0.24, p < 0.001) and GAF-D of the past year (r = 0.28, p = 0.002). Classification reached values of balanced accuracy of 61% for GF-R and GAF-D.
Conclusion
We found that neurocognition was related to psychosocial functioning. More specifically, a deficit in executive functions was associated to poor social and occupational functioning.
