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Metal-Dependent Nucleobase Recognition by Picolinamide
Tekijät: Dengale RA, Thopate SR, Lonnberg T
Kustantaja: WILEY-V C H VERLAG GMBH
Julkaisuvuosi: 2016
Journal: ChemPlusChem
Tietokannassa oleva lehden nimi: CHEMPLUSCHEM
Lehden akronyymi: CHEMPLUSCHEM
Vuosikerta: 81
Numero: 9
Aloitussivu: 978
Lopetussivu: 984
Sivujen määrä: 7
ISSN: 2192-6506
DOI: https://doi.org/10.1002/cplu.201600258
Tiivistelmä
A C-nucleoside featuring picolinamide as the base moiety has been synthesized and incorporated in the middle of a DNA oligonucleotide. The melting temperatures of duplexes formed by this modified oligonucleotide with its unmodified counterparts placing either adenine, cytosine, guanine or thymine opposite to the picolinamide residue were found to be highly dependent on the identity and concentration of transition metal ions in the samples. For example, Ag-I uniquely promoted pairing with adenine and Pd-II with guanine. Pairing with cytosine, on the other hand, was retarded by all of the metal ions studied (Ag-I, Cu-II, Hg-II, Ni-II, Pd-II and Zn-II).
A C-nucleoside featuring picolinamide as the base moiety has been synthesized and incorporated in the middle of a DNA oligonucleotide. The melting temperatures of duplexes formed by this modified oligonucleotide with its unmodified counterparts placing either adenine, cytosine, guanine or thymine opposite to the picolinamide residue were found to be highly dependent on the identity and concentration of transition metal ions in the samples. For example, Ag-I uniquely promoted pairing with adenine and Pd-II with guanine. Pairing with cytosine, on the other hand, was retarded by all of the metal ions studied (Ag-I, Cu-II, Hg-II, Ni-II, Pd-II and Zn-II).
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