A1 Refereed original research article in a scientific journal
Metal-Dependent Nucleobase Recognition by Picolinamide
Authors: Dengale RA, Thopate SR, Lonnberg T
Publisher: WILEY-V C H VERLAG GMBH
Publication year: 2016
Journal: ChemPlusChem
Journal name in source: CHEMPLUSCHEM
Journal acronym: CHEMPLUSCHEM
Volume: 81
Issue: 9
First page : 978
Last page: 984
Number of pages: 7
ISSN: 2192-6506
DOI: https://doi.org/10.1002/cplu.201600258
Abstract
A C-nucleoside featuring picolinamide as the base moiety has been synthesized and incorporated in the middle of a DNA oligonucleotide. The melting temperatures of duplexes formed by this modified oligonucleotide with its unmodified counterparts placing either adenine, cytosine, guanine or thymine opposite to the picolinamide residue were found to be highly dependent on the identity and concentration of transition metal ions in the samples. For example, Ag-I uniquely promoted pairing with adenine and Pd-II with guanine. Pairing with cytosine, on the other hand, was retarded by all of the metal ions studied (Ag-I, Cu-II, Hg-II, Ni-II, Pd-II and Zn-II).
A C-nucleoside featuring picolinamide as the base moiety has been synthesized and incorporated in the middle of a DNA oligonucleotide. The melting temperatures of duplexes formed by this modified oligonucleotide with its unmodified counterparts placing either adenine, cytosine, guanine or thymine opposite to the picolinamide residue were found to be highly dependent on the identity and concentration of transition metal ions in the samples. For example, Ag-I uniquely promoted pairing with adenine and Pd-II with guanine. Pairing with cytosine, on the other hand, was retarded by all of the metal ions studied (Ag-I, Cu-II, Hg-II, Ni-II, Pd-II and Zn-II).
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