The effects of d-amphetamine on extrastriatal dopamine D-2/D-3 receptors: a randomized, double-blind, placebo-controlled PET study with [C-11]FLB 457 in healthy subjects



: Aalto S, Hirvonen J, Kaasinen V, Hagelberg N, Kajander J, Nagren K, Seppala T, Rinne JO, Scheinin H, Hietala J

Publisher: SPRINGER

: 2009

: European Journal of Nuclear Medicine and Molecular Imaging

: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

: EUR J NUCL MED MOL I

: 36

: 3

: 475

: 483

: 9

: 1619-7070

DOI: https://doi.org/10.1007/s00259-008-0969-9


This placebo-controlled study showed that d-amphetamine does not induce marked changes in measures of extrastriatal dopamine D-2/D-3 receptor binding. Our results indicate that [C-11]FLB 457 PET is not a useful method for measuring extrastriatal dopamine release in humans.



Last updated on 2024-26-11 at 13:26