Distribution and Function of Cannabinoid Receptors 1 and 2 in the Rat, Monkey and Human Bladder



: Gratzke C, Streng T, Park A, Christ G, Stief CG, Hedlund P, Andersson KE

Publisher: ELSEVIER SCIENCE INC

: 2009

Journal of Urology

JOURNAL OF UROLOGY

: J UROLOGY

: 181

: 4

: 1939

: 1948

: 10

: 0022-5347

DOI: https://doi.org/10.1016/j.juro.2008.11.079


Conclusions: The distribution of cannabinoid receptor 2 on sensory nerves and in the urothelium, and effects by CP55940 on the micturition interval and threshold pressure suggest a role for cannabinoid receptor 2 in bladder afferent signals. Co-expression of VAChT and cannabinoid receptor 2, and effects by CP55940 on nerve contractions suggest a cannabinoid receptor 2 mediated modulatory effect on cholinergic nerve activity. Anandamide may not be a good tool for cannabinoid receptor studies due to its activity at other receptors.



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