A1 Refereed original research article in a scientific journal
Distribution and Function of Cannabinoid Receptors 1 and 2 in the Rat, Monkey and Human Bladder
Authors: Gratzke C, Streng T, Park A, Christ G, Stief CG, Hedlund P, Andersson KE
Publisher: ELSEVIER SCIENCE INC
Publication year: 2009
Journal:Journal of Urology
Journal name in sourceJOURNAL OF UROLOGY
Journal acronym: J UROLOGY
Volume: 181
Issue: 4
First page : 1939
Last page: 1948
Number of pages: 10
ISSN: 0022-5347
DOI: https://doi.org/10.1016/j.juro.2008.11.079
Abstract
Conclusions: The distribution of cannabinoid receptor 2 on sensory nerves and in the urothelium, and effects by CP55940 on the micturition interval and threshold pressure suggest a role for cannabinoid receptor 2 in bladder afferent signals. Co-expression of VAChT and cannabinoid receptor 2, and effects by CP55940 on nerve contractions suggest a cannabinoid receptor 2 mediated modulatory effect on cholinergic nerve activity. Anandamide may not be a good tool for cannabinoid receptor studies due to its activity at other receptors.
Conclusions: The distribution of cannabinoid receptor 2 on sensory nerves and in the urothelium, and effects by CP55940 on the micturition interval and threshold pressure suggest a role for cannabinoid receptor 2 in bladder afferent signals. Co-expression of VAChT and cannabinoid receptor 2, and effects by CP55940 on nerve contractions suggest a cannabinoid receptor 2 mediated modulatory effect on cholinergic nerve activity. Anandamide may not be a good tool for cannabinoid receptor studies due to its activity at other receptors.
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