Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution But No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits



: Kristiansson K, Perola M, Tikkanen E, Kettunen J, Surakka I, Havulinna AS, Stancakova A, Barnes C, Widen E, Kajantie E, Eriksson JG, Viikari J, Kahonen M, Lehtimoki T, Raitakari OT, Hartikainen AL, Ruokonen A, Pouta A, Jula A, Kangas AJ, Soininen P, Ala-Korpela M, Mannisto S, Jousilahti P, Bonnycastle LL, Jarvelin MR, Kuusisto J, Collins FS, Laakso M, Hurles ME, Palotie A, Peltonen L, Ripatti S, Salomaa V

Publisher: LIPPINCOTT WILLIAMS & WILKINS

: 2012

: Circulation: Cardiovascular Genetics

: CIRCULATION-CARDIOVASCULAR GENETICS

: CIRC-CARDIOVASC GENE

: 2

: 5

: 2

: 242

: 249

: 8

: 1942-325X

DOI: https://doi.org/10.1161/CIRCGENETICS.111.961482


Conclusions-Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and glucose intolerance. (Circ Cardiovasc Genet. 2012;5:242-249.)



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