Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution But No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits - UTU Research Portal

A1 Refereed original research article in a scientific journal

Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution But No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits

Authors: Kristiansson K, Perola M, Tikkanen E, Kettunen J, Surakka I, Havulinna AS, Stancakova A, Barnes C, Widen E, Kajantie E, Eriksson JG, Viikari J, Kahonen M, Lehtimoki T, Raitakari OT, Hartikainen AL, Ruokonen A, Pouta A, Jula A, Kangas AJ, Soininen P, Ala-Korpela M, Mannisto S, Jousilahti P, Bonnycastle LL, Jarvelin MR, Kuusisto J, Collins FS, Laakso M, Hurles ME, Palotie A, Peltonen L, Ripatti S, Salomaa V

Publisher: LIPPINCOTT WILLIAMS & WILKINS

Publication year: 2012

Journal: Circulation: Cardiovascular Genetics

Journal name in source: CIRCULATION-CARDIOVASCULAR GENETICS

Journal acronym: CIRC-CARDIOVASC GENE

Number in series: 2

Volume: 5

Issue: 2

First page : 242

Last page: 249

Number of pages: 8

ISSN: 1942-325X

DOI: https://doi.org/10.1161/CIRCGENETICS.111.961482

Abstract

Conclusions-Our findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and glucose intolerance. (Circ Cardiovasc Genet. 2012;5:242-249.)