Comparison of pharmacokinetic profile of levodopa throughout the day between levodopa/carbidopa/entacapone and levodopa/carbidopa when administered four or five times daily



: Kuoppamaki M, Korpela K, Marttila R, Kaasinen V, Hartikainen P, Lyytinen J, Kaakkola S, Hanninen J, Loyttyniemi E, Kailajarvi M, Ruokoniemi P, Ellmen J

Publisher: SPRINGER

: 2009

: European Journal of Clinical Pharmacology

: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

: EUR J CLIN PHARMACOL

: 65

: 5

: 443

: 455

: 13

: 0031-6970

DOI: https://doi.org/10.1007/s00228-009-0622-y


The present results on the differences in levodopa PK between LCE and LC provide a basis to evaluate the relationship of levodopa PK and the induction of motor complications in an on-going study in early Parkinson's disease using similar dosing regimens.



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