A1 Refereed original research article in a scientific journal
The Cholinergic Potential, the Vagus Nerve and Challenges in Treatment of Traumatic Brain Injury
Authors: Uteshev VV, Tenovuo O, Gaidhani N
Publisher: BENTHAM SCIENCE PUBL LTD
Publication year: 2016
Journal: Current Pharmaceutical Design
Journal name in source: CURRENT PHARMACEUTICAL DESIGN
Journal acronym: CURR PHARM DESIGN
Volume: 22
Issue: 14
First page : 2083
Last page: 2092
Number of pages: 10
ISSN: 1381-6128
eISSN: 1873-4286
DOI: https://doi.org/10.2174/1381612822666160127111630(external)
Abstract
Existing treatments of traumatic brain injury (TBI) have failed to reverse tremendous losses in productivity, independence and overall quality of life among TBI victims and therefore, cannot be viewed as sufficient. Although there is no shortage of promising basic concepts that may translate to efficacious therapies after TBI, the accumulated knowledge has yet to deliver treatments that adequately meet clinical and social demands. In this article, we discuss novel concepts, recent advances and accompanying challenges in developing cholinergic and related therapies after TBI.
Existing treatments of traumatic brain injury (TBI) have failed to reverse tremendous losses in productivity, independence and overall quality of life among TBI victims and therefore, cannot be viewed as sufficient. Although there is no shortage of promising basic concepts that may translate to efficacious therapies after TBI, the accumulated knowledge has yet to deliver treatments that adequately meet clinical and social demands. In this article, we discuss novel concepts, recent advances and accompanying challenges in developing cholinergic and related therapies after TBI.
UTU Research Portal