Voriconazole drastically increases exposure to oral oxycodone



: Hagelberg N, Nieminen T, Saari T, Neuvonen M, Neuvonen P, Laine K, Olkkola K

Publisher: SPRINGER

: 2009

: European Journal of Clinical Pharmacology

: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

: EUR J CLIN PHARMACOL

: 65

: 3

: 263

: 271

: 9

: 0031-6970

DOI: https://doi.org/10.1007/s00228-008-0568-5


Voriconazole inhibits the CYP3A-mediated N-demethylation of oxycodone, drastically increasing exposure to oral oxycodone. Clinically, lower doses of oxycodone may be needed during voriconazole treatment to avoid opioid-related adverse effects especially after repeated dosing.



Last updated on 2024-26-11 at 19:58