A1 Refereed original research article in a scientific journal
Voriconazole drastically increases exposure to oral oxycodone
Authors: Hagelberg N, Nieminen T, Saari T, Neuvonen M, Neuvonen P, Laine K, Olkkola K
Publisher: SPRINGER
Publication year: 2009
Journal: European Journal of Clinical Pharmacology
Journal name in source: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Journal acronym: EUR J CLIN PHARMACOL
Volume: 65
Issue: 3
First page : 263
Last page: 271
Number of pages: 9
ISSN: 0031-6970
DOI: https://doi.org/10.1007/s00228-008-0568-5
Abstract
Voriconazole inhibits the CYP3A-mediated N-demethylation of oxycodone, drastically increasing exposure to oral oxycodone. Clinically, lower doses of oxycodone may be needed during voriconazole treatment to avoid opioid-related adverse effects especially after repeated dosing.
Voriconazole inhibits the CYP3A-mediated N-demethylation of oxycodone, drastically increasing exposure to oral oxycodone. Clinically, lower doses of oxycodone may be needed during voriconazole treatment to avoid opioid-related adverse effects especially after repeated dosing.
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