Genetic Profiling Using Genome-Wide Significant Coronary Artery Disease Risk Variants Does Not Improve the Prediction of Subclinical Atherosclerosis: The Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey - A Meta-Analysis of Three Independent Studies
: Hernesniemi JA, Seppala I, Lyytikainen LP, Mononen N, Oksala N, Hutri-Kahonen N, Juonala M, Taittonen L, Smith EN, Schork NJ, Chen W, Srinivasan SR, Berenson GS, Murray SS, Laitinen T, Jula A, Kettunen J, Ripatti S, Laaksonen R, Viikari J, Kahonen M, Raitakari OT, Lehtimaki T
Publisher: PUBLIC LIBRARY SCIENCE
: 2012
: PLoS ONE
: PLOS ONE
: PLOS ONE
: ARTN e28931
: 1
: 7
: 1
: 10
: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0028931
Conclusion: Genetic profiling, by using known CAD risk variants, should not improve risk stratification for subclinical atherosclerosis beyond conventional risk factors among healthy young adults.