The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations

: Jermendy A, Szatmari I, Laine AP, Lukacs K, Horvath KH, Korner A, Madacsy L, Veijola R, Simell O, Knip M, Ilonen J, Hermann R

Publisher: SPRINGER

: 2010

: Diabetologia

: DIABETOLOGIA

: 1

: 53

: 1

: 98

: 102

: 5

: 0012-186X

DOI: https://doi.org/10.1007/s00125-009-1561-y

This study represents the first independent confirmation of the association between type 1 diabetes and the IFIH1 gene in Hungarian and Finnish populations. Summarising the data published so far, a clear association between the Ala946Thr polymorphism and type 1 diabetes was detected, with an apparent difference in the contribution to disease susceptibility in different populations of European ancestry.