Cardiomyocyte Apoptosis After Antegrade and Retrograde Cardioplegia During Aortic Valve Surgery



: Vahasilta T, Malmberg M, Saraste A, Koskenvuo JW, Parkka JP, Valtonen M, Leino K, Nuutila K, Saukko P, Kuttila K, Savunen T

Publisher: ELSEVIER SCIENCE INC

: 2011

: Annals of Thoracic Surgery

: ANNALS OF THORACIC SURGERY

: ANN THORAC SURG

: 4

: 92

: 4

: 1351

: 1357

: 7

: 0003-4975

DOI: https://doi.org/10.1016/j.athoracsur.2011.05.065(external)


Conclusions. In contrast to antegrade cardioplegia, retrograde cardioplegia is associated with increased cardiomyocyte apoptosis, impaired immediate postoperative systolic function, and lack of long-term favorable left ventricle remodeling after aortic valve replacement, suggesting inadequate myocardial protection. (Ann Thorac Surg 2011;92:1351-7) (C) 2011 by The Society of Thoracic Surgeons



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