A1 Refereed original research article in a scientific journal

Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone



Authors: Gronlund J, Saari TI, Hagelberg NM, Neuvonen PJ, Olkkola KT, Laine K

Publisher: WILEY-BLACKWELL

Publication year: 2010

Journal: British Journal of Clinical Pharmacology

Journal name in source: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Journal acronym: BRIT J CLIN PHARMACO

Number in series: 1

Volume: 70

Issue: 1

First page : 78

Last page: 87

Number of pages: 10

ISSN: 0306-5251

DOI: https://doi.org/10.1111/j.1365-2125.2010.03653.x


Abstract
Drug interactions arising from CYP2D6 inhibition most likely have minor clinical importance for oral oxycodone if the function of the CYP3A4 pathway is normal. When both CYP2D6 and CYP3A4 pathways are inhibited, the exposure to oral oxycodone is increased substantially.



Last updated on 2024-26-11 at 11:36