Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone




Saari TI, Gronlund J, Hagelberg NM, Neuvonen M, Laine K, Neuvonen PJ, Olkkola KT

PublisherSPRINGER

2010

European Journal of Clinical Pharmacology

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

EUR J CLIN PHARMACOL

4

66

4

387

397

11

0031-6970

DOIhttps://doi.org/10.1007/s00228-009-0775-8



Itraconazole increased the exposure to oxycodone by inhibiting its CYP3A4-mediated N-demethylation. The clinical use of itraconazole in patients receiving multiple doses of oxycodone for pain relief may increase the risk of opioid-associated adverse effects.



Last updated on 2024-26-11 at 22:24