Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone
: Saari TI, Gronlund J, Hagelberg NM, Neuvonen M, Laine K, Neuvonen PJ, Olkkola KT
Publisher: SPRINGER
: 2010
: European Journal of Clinical Pharmacology
: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
: EUR J CLIN PHARMACOL
: 4
: 66
: 4
: 387
: 397
: 11
: 0031-6970
DOI: https://doi.org/10.1007/s00228-009-0775-8
Itraconazole increased the exposure to oxycodone by inhibiting its CYP3A4-mediated N-demethylation. The clinical use of itraconazole in patients receiving multiple doses of oxycodone for pain relief may increase the risk of opioid-associated adverse effects.