A1 Refereed original research article in a scientific journal

Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone



Authors: Saari TI, Gronlund J, Hagelberg NM, Neuvonen M, Laine K, Neuvonen PJ, Olkkola KT

Publisher: SPRINGER

Publication year: 2010

Journal: European Journal of Clinical Pharmacology

Journal name in source: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Journal acronym: EUR J CLIN PHARMACOL

Number in series: 4

Volume: 66

Issue: 4

First page : 387

Last page: 397

Number of pages: 11

ISSN: 0031-6970

DOI: https://doi.org/10.1007/s00228-009-0775-8


Abstract
Itraconazole increased the exposure to oxycodone by inhibiting its CYP3A4-mediated N-demethylation. The clinical use of itraconazole in patients receiving multiple doses of oxycodone for pain relief may increase the risk of opioid-associated adverse effects.



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