Enabling [18F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [18F]-anti-microRNA-21 as an example

: Li XG, Roivainen A, Bergman J, Heinonen A, Bengel F, Thum T, Knuuti J

Publisher: ROYAL SOC CHEMISTRY

: 2015

: Chemical Communications

: CHEMICAL COMMUNICATIONS

: CHEM COMMUN

: 51

: 48

: 9821

: 9824

: 4

: 1359-7345

: 1364-548X

A bicyclononyne-based prosthetic group has been developed for ¹⁸F-labeling of anti-microRNA-21, an oligonucleotide, in a near-stoichiometric manner.