Enabling [18F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [18F]-anti-microRNA-21 as an example - UTU Research Portal

A1 Refereed original research article in a scientific journal

Enabling [18F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [18F]-anti-microRNA-21 as an example

Authors: Li XG, Roivainen A, Bergman J, Heinonen A, Bengel F, Thum T, Knuuti J

Publisher: ROYAL SOC CHEMISTRY

Publication year: 2015

Journal: Chemical Communications

Journal name in source: CHEMICAL COMMUNICATIONS

Journal acronym: CHEM COMMUN

Volume: 51

Issue: 48

First page : 9821

Last page: 9824

Number of pages: 4

ISSN: 1359-7345

eISSN: 1364-548X

DOI: https://doi.org/10.1039/c5cc02618k

Abstract

A bicyclononyne-based prosthetic group has been developed for ¹⁸F-labeling of anti-microRNA-21, an oligonucleotide, in a near-stoichiometric manner.