B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
Hydrolysis and methanolysis of the phenyl ester of thymidine 3',5'-cyclic monophosphate: pH-dependent competition between PO and CO bond ruptures
Tekijät: Oivanen M, Varila J, Hankamaki T, Koole LH, Lonnberg H
Kustantaja: INST ORGANIC CHEM AND BIOCHEM
Julkaisuvuosi: 1996
Lehti:: Collection of Czechoslovak Chemical Communications
Tietokannassa oleva lehden nimi: COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
Lehden akronyymi: COLLECT CZECH CHEM C
Vuosikerta: 61
Aloitussivu: S26
Lopetussivu: S29
Sivujen määrä: 4
ISSN: 0010-0765
Tiivistelmä
pH-Rate profiles and product distributions for the hydrolytic reactions of the cis-phenyl ester of thymidine 3',5'-cyclic monophosphate have been determined over the pH-range 0-14. The pH-independent hydrolysis (pH 2-7) of the phosphotriester moiety appears to proceed mainly by cleavage of the C5'O bund, whereas the hydroxide- and hydronium-ion-catalyzed reactions involve rupture of one of the PO bonds.
pH-Rate profiles and product distributions for the hydrolytic reactions of the cis-phenyl ester of thymidine 3',5'-cyclic monophosphate have been determined over the pH-range 0-14. The pH-independent hydrolysis (pH 2-7) of the phosphotriester moiety appears to proceed mainly by cleavage of the C5'O bund, whereas the hydroxide- and hydronium-ion-catalyzed reactions involve rupture of one of the PO bonds.
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