B1 Non-refereed article in a scientific journal
Hydrolysis and methanolysis of the phenyl ester of thymidine 3',5'-cyclic monophosphate: pH-dependent competition between PO and CO bond ruptures
Authors: Oivanen M, Varila J, Hankamaki T, Koole LH, Lonnberg H
Publisher: INST ORGANIC CHEM AND BIOCHEM
Publication year: 1996
Journal:: Collection of Czechoslovak Chemical Communications
Journal name in source: COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
Journal acronym: COLLECT CZECH CHEM C
Volume: 61
First page : S26
Last page: S29
Number of pages: 4
ISSN: 0010-0765
Abstract
pH-Rate profiles and product distributions for the hydrolytic reactions of the cis-phenyl ester of thymidine 3',5'-cyclic monophosphate have been determined over the pH-range 0-14. The pH-independent hydrolysis (pH 2-7) of the phosphotriester moiety appears to proceed mainly by cleavage of the C5'O bund, whereas the hydroxide- and hydronium-ion-catalyzed reactions involve rupture of one of the PO bonds.
pH-Rate profiles and product distributions for the hydrolytic reactions of the cis-phenyl ester of thymidine 3',5'-cyclic monophosphate have been determined over the pH-range 0-14. The pH-independent hydrolysis (pH 2-7) of the phosphotriester moiety appears to proceed mainly by cleavage of the C5'O bund, whereas the hydroxide- and hydronium-ion-catalyzed reactions involve rupture of one of the PO bonds.
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