Reducing Unnecessary Biopsy During Prostate Cancer Screening Using a Four-Kallikrein Panel: An Independent Replication



: Vickers A, Cronin A, Roobol M, Savage C, Peltola M, Pettersson K, Scardino PT, Schroder F, Lilja H

Publisher: AMER SOC CLINICAL ONCOLOGY

: 2010

: Journal of Clinical Oncology

: JOURNAL OF CLINICAL ONCOLOGY

: J CLIN ONCOL

: 15

: 28

: 15

: 2493

: 2498

: 6

: 0732-183X

DOI: https://doi.org/10.1200/JCO.2009.24.1968


We have replicated our previously published finding that a panel of four kallikreins can predict the result of biopsy for prostate cancer in men with elevated PSA. Use of this panel would dramatically reduce biopsy rates. A small number of men with cancer would be advised against immediate biopsy, but these men would have predominately low-stage, low-grade disease.



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