A1 Refereed original research article in a scientific journal

Reducing Unnecessary Biopsy During Prostate Cancer Screening Using a Four-Kallikrein Panel: An Independent Replication




AuthorsVickers A, Cronin A, Roobol M, Savage C, Peltola M, Pettersson K, Scardino PT, Schroder F, Lilja H

PublisherAMER SOC CLINICAL ONCOLOGY

Publication year2010

JournalJournal of Clinical Oncology

Journal name in sourceJOURNAL OF CLINICAL ONCOLOGY

Journal acronymJ CLIN ONCOL

Number in series15

Volume28

Issue15

First page 2493

Last page2498

Number of pages6

ISSN0732-183X

DOIhttps://doi.org/10.1200/JCO.2009.24.1968


Abstract
We have replicated our previously published finding that a panel of four kallikreins can predict the result of biopsy for prostate cancer in men with elevated PSA. Use of this panel would dramatically reduce biopsy rates. A small number of men with cancer would be advised against immediate biopsy, but these men would have predominately low-stage, low-grade disease.



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