A1 Refereed original research article in a scientific journal

Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions



Authors: Roncal C, Buysschaert I, Gerdes N, Georgiadou M, Ovchinnikova O, Fischer C, Stassen JM, Moons L, Collen D, De Bock K, Hansson GK, Carmeliet P

Publisher: OXFORD UNIV PRESS

Publication year: 2010

Journal: Cardiovascular Research

Journal name in source: CARDIOVASCULAR RESEARCH

Journal acronym: CARDIOVASC RES

Volume: 86

Issue: 1

First page : 29

Last page: 36

Number of pages: 8

ISSN: 0008-6363

DOI: https://doi.org/10.1093/cvr/cvp380


Abstract
These pharmacological alpha PlGF mAb results confirm previous genetic evidence that inhibition of PlGF slows down early atherosclerotic lesion development. Furthermore, the phenocopy of genetic and pharmacological loss-of-function strategies underscores that alpha PlGF acts by selectively neutralizing PlGF.



Last updated on 2024-26-11 at 11:50