A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Dietary phytoestrogens and their role in hormonally dependent disease
Tekijät: Strauss L, Santti R, Saarinen N, Streng T, Joshi S, Makela S
Kustantaja: ELSEVIER SCI IRELAND LTD
Julkaisuvuosi: 1998
Lehti:: Toxicology Letters
Tietokannassa oleva lehden nimi: TOXICOLOGY LETTERS
Lehden akronyymi: TOXICOL LETT
Vuosikerta: 103
Aloitussivu: 349
Lopetussivu: 354
Sivujen määrä: 6
ISSN: 0378-4274
DOI: https://doi.org/10.1016/S0378-4274(98)00332-4
Tiivistelmä
Epidemiological studies suggest that diets rich in phytoestrogens (plant estrogens), particularly soy and unrefined grain products, may be associated with low risk of breast and prostate cancer. It has also been proposed that dietary phytoestrogens could play a role in the prevention of other estrogen-related conditions, namely cardiovascular disease, menopausal symptoms and post-menopausal osteoporosis. However, there is no direct evidence for the beneficial effects of phytoestrogens in humans. All information is based on consumption of phytoestrogen-rich diets, and the causal relationship and the mechanisms of phytoestrogen action in humans still remain to be demonstrated. In addition, the possible adverse effects of phytoestrogens have not been evaluated. It is plausible that phytoestrogens, as any exogenous hormonally active agent, might also cause adverse effects in the endocrine system, i.e. act as endocrine disrupters. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
Epidemiological studies suggest that diets rich in phytoestrogens (plant estrogens), particularly soy and unrefined grain products, may be associated with low risk of breast and prostate cancer. It has also been proposed that dietary phytoestrogens could play a role in the prevention of other estrogen-related conditions, namely cardiovascular disease, menopausal symptoms and post-menopausal osteoporosis. However, there is no direct evidence for the beneficial effects of phytoestrogens in humans. All information is based on consumption of phytoestrogen-rich diets, and the causal relationship and the mechanisms of phytoestrogen action in humans still remain to be demonstrated. In addition, the possible adverse effects of phytoestrogens have not been evaluated. It is plausible that phytoestrogens, as any exogenous hormonally active agent, might also cause adverse effects in the endocrine system, i.e. act as endocrine disrupters. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
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