A1 Refereed original research article in a scientific journal
Dietary phytoestrogens and their role in hormonally dependent disease
Authors: Strauss L, Santti R, Saarinen N, Streng T, Joshi S, Makela S
Publisher: ELSEVIER SCI IRELAND LTD
Publication year: 1998
Journal:: Toxicology Letters
Journal name in source: TOXICOLOGY LETTERS
Journal acronym: TOXICOL LETT
Volume: 103
First page : 349
Last page: 354
Number of pages: 6
ISSN: 0378-4274
DOI: https://doi.org/10.1016/S0378-4274(98)00332-4
Abstract
Epidemiological studies suggest that diets rich in phytoestrogens (plant estrogens), particularly soy and unrefined grain products, may be associated with low risk of breast and prostate cancer. It has also been proposed that dietary phytoestrogens could play a role in the prevention of other estrogen-related conditions, namely cardiovascular disease, menopausal symptoms and post-menopausal osteoporosis. However, there is no direct evidence for the beneficial effects of phytoestrogens in humans. All information is based on consumption of phytoestrogen-rich diets, and the causal relationship and the mechanisms of phytoestrogen action in humans still remain to be demonstrated. In addition, the possible adverse effects of phytoestrogens have not been evaluated. It is plausible that phytoestrogens, as any exogenous hormonally active agent, might also cause adverse effects in the endocrine system, i.e. act as endocrine disrupters. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
Epidemiological studies suggest that diets rich in phytoestrogens (plant estrogens), particularly soy and unrefined grain products, may be associated with low risk of breast and prostate cancer. It has also been proposed that dietary phytoestrogens could play a role in the prevention of other estrogen-related conditions, namely cardiovascular disease, menopausal symptoms and post-menopausal osteoporosis. However, there is no direct evidence for the beneficial effects of phytoestrogens in humans. All information is based on consumption of phytoestrogen-rich diets, and the causal relationship and the mechanisms of phytoestrogen action in humans still remain to be demonstrated. In addition, the possible adverse effects of phytoestrogens have not been evaluated. It is plausible that phytoestrogens, as any exogenous hormonally active agent, might also cause adverse effects in the endocrine system, i.e. act as endocrine disrupters. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
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