B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
A GENERAL-APPROACH FOR THE HYDROXY GROUP FUNCTIONALIZATION OF SYNTHETIC OLIGONUCLEOTIDES
Tekijät: GUZAEV A, HOVINEN J, AZHAYEV A, LONNBERG H
Kustantaja: MARCEL DEKKER INC
Julkaisuvuosi: 1995
Lehti:: Nucleosides & nucleotides
Tietokannassa oleva lehden nimi: NUCLEOSIDES & NUCLEOTIDES
Lehden akronyymi: NUCLEOS NUCLEOT
Vuosikerta: 14
Numero: 3-5
Aloitussivu: 833
Lopetussivu: 837
Sivujen määrä: 5
ISSN: 0732-8311
DOI: https://doi.org/10.1080/15257779508012483
Tiivistelmä
Generally applicable non-nucleosidic solid supports and phosphoramidite building blocks that enable attachment of various tethers to the hydroxy groups of oligonucleotides were prepared. The key feature of the structure of these reagents is an ester bond of moderate reactivity which allows postsynthetic introduction of tethers by reaction with substituted alkylamines.
Generally applicable non-nucleosidic solid supports and phosphoramidite building blocks that enable attachment of various tethers to the hydroxy groups of oligonucleotides were prepared. The key feature of the structure of these reagents is an ester bond of moderate reactivity which allows postsynthetic introduction of tethers by reaction with substituted alkylamines.
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