B1 Non-refereed article in a scientific journal
A GENERAL-APPROACH FOR THE HYDROXY GROUP FUNCTIONALIZATION OF SYNTHETIC OLIGONUCLEOTIDES
Authors: GUZAEV A, HOVINEN J, AZHAYEV A, LONNBERG H
Publisher: MARCEL DEKKER INC
Publication year: 1995
Journal:: Nucleosides & nucleotides
Journal name in source: NUCLEOSIDES & NUCLEOTIDES
Journal acronym: NUCLEOS NUCLEOT
Volume: 14
Issue: 3-5
First page : 833
Last page: 837
Number of pages: 5
ISSN: 0732-8311
DOI: https://doi.org/10.1080/15257779508012483
Abstract
Generally applicable non-nucleosidic solid supports and phosphoramidite building blocks that enable attachment of various tethers to the hydroxy groups of oligonucleotides were prepared. The key feature of the structure of these reagents is an ester bond of moderate reactivity which allows postsynthetic introduction of tethers by reaction with substituted alkylamines.
Generally applicable non-nucleosidic solid supports and phosphoramidite building blocks that enable attachment of various tethers to the hydroxy groups of oligonucleotides were prepared. The key feature of the structure of these reagents is an ester bond of moderate reactivity which allows postsynthetic introduction of tethers by reaction with substituted alkylamines.
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