Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects



: Yoo H, Iirola T, Vilo S, Manner T, Aantaa R, Lahtinen M, Scheinin M, Olkkola KT, Jusko WJ

Publisher: SPRINGER HEIDELBERG

: 2015

: European Journal of Clinical Pharmacology

: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

: EUR J CLIN PHARMACOL

: 71

: 10

: 1197

: 1207

: 11

: 0031-6970

DOI: https://doi.org/10.1007/s00228-015-1913-0


Conclusion The comprehensive panel of two biomarkers and seven response measures were well captured by the population PK/PD models. The subjects were more sensitive to the CNS (lower EC (50) values) than cardiovascular effects of dexmedetomidine.




Last updated on 2024-26-11 at 15:21