A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Mechanistic Insights into Sympathetic Neuronal Regeneration Multitracer Molecular Imaging of Catecholamine Handling After Cardiac Transplantation
Tekijät: Bravo PE, Lautamaki R, Carter D, Holt DP, Nekolla SG, Dannals RF, Russell SD, Bengel FM
Kustantaja: LIPPINCOTT WILLIAMS & WILKINS
Julkaisuvuosi: 2015
Journal: Circulation: Cardiovascular Imaging
Tietokannassa oleva lehden nimi: CIRCULATION-CARDIOVASCULAR IMAGING
Lehden akronyymi: CIRC-CARDIOVASC IMAG
Artikkelin numero: ARTN e003507
Vuosikerta: 8
Numero: 8
Sivujen määrä: 7
ISSN: 1941-9651
DOI: https://doi.org/10.1161/CIRCIMAGING.115.003507
Conclusions Regeneration of subcellular components of sympathetic nerve terminal function does not occur simultaneously. In the reinnervating transplanted heart, a region with normal catecholamine transport and vesicular storage is surrounded by a borderzone, where transport is already restored but vesicular storage remains inefficient, suggesting that vesicular storage is a more delicate mechanism. This observation may have implications for other pathologies involving cardiac autonomic innervation.
