Mechanistic Insights into Sympathetic Neuronal Regeneration Multitracer Molecular Imaging of Catecholamine Handling After Cardiac Transplantation - UTU Research Portal

A1 Refereed original research article in a scientific journal

Mechanistic Insights into Sympathetic Neuronal Regeneration Multitracer Molecular Imaging of Catecholamine Handling After Cardiac Transplantation

Authors: Bravo PE, Lautamaki R, Carter D, Holt DP, Nekolla SG, Dannals RF, Russell SD, Bengel FM

Publisher: LIPPINCOTT WILLIAMS & WILKINS

Publication year: 2015

Journal: Circulation: Cardiovascular Imaging

Journal name in source: CIRCULATION-CARDIOVASCULAR IMAGING

Journal acronym: CIRC-CARDIOVASC IMAG

Article number: ARTN e003507

Volume: 8

Issue: 8

Number of pages: 7

ISSN: 1941-9651

DOI: https://doi.org/10.1161/CIRCIMAGING.115.003507

Abstract

Conclusions Regeneration of subcellular components of sympathetic nerve terminal function does not occur simultaneously. In the reinnervating transplanted heart, a region with normal catecholamine transport and vesicular storage is surrounded by a borderzone, where transport is already restored but vesicular storage remains inefficient, suggesting that vesicular storage is a more delicate mechanism. This observation may have implications for other pathologies involving cardiac autonomic innervation.