Pregnancy Complications Following Prenatal Exposure to SSRIs or Maternal Psychiatric Disorders: Results From Population-Based National Register Data - UTU Research Portal

A1 Refereed original research article in a scientific journal

Pregnancy Complications Following Prenatal Exposure to SSRIs or Maternal Psychiatric Disorders: Results From Population-Based National Register Data

Authors: Malm H, Sourander A, Gissler M, Gyllenberg D, Hinkka-Yli-Salomaki S, McKeague IW, Artama M, Brown AS

Publisher: AMER PSYCHIATRIC PUBLISHING, INC

Publication year: 2015

Journal: American Journal of Psychiatry

Journal name in source: AMERICAN JOURNAL OF PSYCHIATRY

Journal acronym: AM J PSYCHIAT

Volume: 172

Issue: 12

First page : 1224

Last page: 1232

Number of pages: 9

ISSN: 0002-953X

DOI: https://doi.org/10.1176/appi.ajp.2015.14121575

Abstract

Conclusions: In a large national birth cohort, treatment of maternal psychiatric disorders with SSRIs during pregnancy was related to a lower risk of preterm birth and cesarean section but a higher risk of neonatal maladaptation. The findings provide novel evidence for a protective rote of SSRIs on some deleterious reproductive outcomes, possibly by reducing maternal depressive symptoms. The divergent findings suggest that clinical decisions on SSRI use during pregnancy should be individualized, taking into account the mother's psychiatric and reproductive history.