A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Synthesis of 3',5'-Cyclic Phosphate and Thiophosphate Esters of 2'-C-Methyl Ribonucleosides
Tekijät: Leisvuori A, Ahmed Z, Ora M, Beigelman L, Blatt L, Lonnberg H
Kustantaja: WILEY-V C H VERLAG GMBH
Julkaisuvuosi: 2012
Journal: Helvetica Chimica Acta
Tietokannassa oleva lehden nimi: HELVETICA CHIMICA ACTA
Lehden akronyymi: HELV CHIM ACTA
Numero sarjassa: 9
Vuosikerta: 95
Numero: 9
Aloitussivu: 1512
Lopetussivu: 1520
Sivujen määrä: 9
ISSN: 0018-019X
DOI: https://doi.org/10.1002/hlca.201200099
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/1441658
2'-C-Methylnucleosides are known to exhibit antiviral activity against Hepatitis C virus. Since the inhibitory activity depends on their intracellular conversion to 5'-triphosphates, dosing as appropriately protected 5'-phosphates or 5'-phosphorothioates appears attractive. For this purpose, four potential pro-drugs of 2'-C-methylguanosine, i.e., 3',5'-cyclic phosphorothioate of 2'-C-methylguanosine and 2'-C,O6-dimethylguanosine, 1 and 2, respectively, the S-[(pivaloyloxy)methyl] ester of 2'-C,O6-dimethylguanosine 3',5'-cyclic phosphorothioate and the O-methyl ester of 2'-C,O6-dimethylguanosine 3',5'-cyclic phosphate, 3 and 4, respectively, have been prepared.
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