Effects of Acute and One-Week Fatty Acid Lowering on Cardiac Function and Insulin Sensitivity in Relation with Myocardial and Muscle Fat and Adiponectin Levels

: Lehto HR, Parkka J, Borra R, Tuunanen H, Lepomaki V, Parkkola R, Knuuti J, Nuutila P, Iozzo P

Publisher: ENDOCRINE SOC

: 2012

: Journal of Clinical Endocrinology and Metabolism

: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

: J CLIN ENDOCR METAB

: 9

: 97

: 9

: 3277

: 3284

: 8

: 0021-972X

DOI: https://doi.org/10.1210/jc.2012-1219

Conclusions: A 1-wk FFA depletion suppressed cardiac function and improved insulin sensitivity. Intracellular triglyceride deposits in the heart and skeletal muscle played no role in the observed changes. Our data show that FFA participate in the physiological regulation of adipokine levels. (J Clin Endocrinol Metab 97: 3277-3284, 2012)