Distribution and Dynamics of Transcription-Associated Proteins during Parvovirus Infection



: Ihalainen TO, Willman SF, Niskanen EA, Paloheimo O, Smolander H, Laurila JP, Kaikkonen MU, Vihinen-Ranta M

Publisher: AMER SOC MICROBIOLOGY

: 2012

Journal of Virology

JOURNAL OF VIROLOGY

: J VIROL

: 24

: 86

: 24

: 13779

: 13784

: 6

: 0022-538X

: 1098-5514

DOI: https://doi.org/10.1128/JVI.01625-12


Canine parvovirus (CPV) infection leads to reorganization of nuclear proteinaceous subcompartments. Our studies showed that virus infection causes a time-dependent increase in the amount of viral nonstructural protein NS1 mRNA. Fluorescence recovery after photobleaching showed that the recovery kinetics of nuclear transcription-associated proteins, TATA binding protein (TBP), transcription factor IIB (TFIIB), and poly(A) binding protein nuclear 1 (PABPN1) were different in infected and noninfected cells, pointing to virus-induced alterations in binding dynamics of these proteins.



Last updated on 2024-26-11 at 14:58