A1 Refereed original research article in a scientific journal
Distribution and Dynamics of Transcription-Associated Proteins during Parvovirus Infection
Authors: Ihalainen TO, Willman SF, Niskanen EA, Paloheimo O, Smolander H, Laurila JP, Kaikkonen MU, Vihinen-Ranta M
Publisher: AMER SOC MICROBIOLOGY
Publication year: 2012
Journal: Journal of Virology
Journal name in source: JOURNAL OF VIROLOGY
Journal acronym: J VIROL
Number in series: 24
Volume: 86
Issue: 24
First page : 13779
Last page: 13784
Number of pages: 6
ISSN: 0022-538X
eISSN: 1098-5514
DOI: https://doi.org/10.1128/JVI.01625-12
Abstract
Canine parvovirus (CPV) infection leads to reorganization of nuclear proteinaceous subcompartments. Our studies showed that virus infection causes a time-dependent increase in the amount of viral nonstructural protein NS1 mRNA. Fluorescence recovery after photobleaching showed that the recovery kinetics of nuclear transcription-associated proteins, TATA binding protein (TBP), transcription factor IIB (TFIIB), and poly(A) binding protein nuclear 1 (PABPN1) were different in infected and noninfected cells, pointing to virus-induced alterations in binding dynamics of these proteins.
Canine parvovirus (CPV) infection leads to reorganization of nuclear proteinaceous subcompartments. Our studies showed that virus infection causes a time-dependent increase in the amount of viral nonstructural protein NS1 mRNA. Fluorescence recovery after photobleaching showed that the recovery kinetics of nuclear transcription-associated proteins, TATA binding protein (TBP), transcription factor IIB (TFIIB), and poly(A) binding protein nuclear 1 (PABPN1) were different in infected and noninfected cells, pointing to virus-induced alterations in binding dynamics of these proteins.
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