Metabolite Profiling and Cardiovascular Event Risk A Prospective Study of 3 Population-Based Cohorts

: Wurtz P, Havulinna AS, Soininen P, Tynkkynen T, Prieto-Merino D, Tillin T, Ghorbani A, Artati A, Wang Q, Tiainen M, Kangas AJ, Kettunen J, Kaikkonen J, Mikkila V, Jula A, Kahonen M, Lehtimaki T, Lawlor DA, Gaunt TR, Hughes AD, Sattar N, Illig T, Adamski J, Wang TJ, Perola M, Ripatti S, Vasan RS, Raitakari OT, Gerszten RE, Casas JP, Chaturvedi N, Ala-Korpela M, Salomaa V

Publisher: LIPPINCOTT WILLIAMS & WILKINS

: 2015

: Circulation

: CIRCULATION

: 131

: 9

: 774

: 785

: 37

: 0009-7322

DOI: https://doi.org/10.1161/CIRCULATIONAHA.114.013116

Conclusions-Metabolite profiling in large prospective cohorts identified phenylalanine, monounsaturated fatty acids, and polyunsaturated fatty acids as biomarkers for cardiovascular risk. This study substantiates the value of high-throughput metabolomics for biomarker discovery and improved risk assessment.