A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern



: Sinner MF, Porthan K, Noseworthy PA, Havulinna AS, Tikkanen JT, Muller-Nurasyid M, Peloso G, Ulivi S, Beckmann BM, Brockhaus AC, Cooper RR, Gasparini P, Hengstenberg C, Hwang SJ, Iorio A, Junttila MJ, Klopp N, Kahonen M, Laaksonen MA, Lehtimaki T, Lichtner P, Lyytikainen LP, Martens E, Meisinger C, Meitinger T, Merchant FM, Nieminen MS, Peters A, Pietila A, Perz S, Oikarinen L, Raitakari O, Reinhard W, Silander K, Thorand B, Wichmann HE, Sinagra G, Viikari J, O'Donnell CJ, Ellinor PT, Huikuri HV, Kaab S, Newton-Cheh C, Salomaa V

Publisher: ELSEVIER SCIENCE INC

: 2012

: Heart Rhythm

: HEART RHYTHM

: HEART RHYTHM

: 10

: 9

: 10

: 1627

: 1634

: 8

: 1547-5271

DOI: https://doi.org/10.1016/j.hrthm.2012.06.008


CONCLUSIONS In a genome-wide association study, we were not able to reliably identify genetic variants predisposing to ERP, presumably due to insufficient statistical power and phenotype heterogeneity. The reported heritability of ERP warrants continued investigation in larger well-phenotyped populations.



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