A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern - UTU Research Portal

A1 Refereed original research article in a scientific journal

A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern

Authors: Sinner MF, Porthan K, Noseworthy PA, Havulinna AS, Tikkanen JT, Muller-Nurasyid M, Peloso G, Ulivi S, Beckmann BM, Brockhaus AC, Cooper RR, Gasparini P, Hengstenberg C, Hwang SJ, Iorio A, Junttila MJ, Klopp N, Kahonen M, Laaksonen MA, Lehtimaki T, Lichtner P, Lyytikainen LP, Martens E, Meisinger C, Meitinger T, Merchant FM, Nieminen MS, Peters A, Pietila A, Perz S, Oikarinen L, Raitakari O, Reinhard W, Silander K, Thorand B, Wichmann HE, Sinagra G, Viikari J, O'Donnell CJ, Ellinor PT, Huikuri HV, Kaab S, Newton-Cheh C, Salomaa V

Publisher: ELSEVIER SCIENCE INC

Publication year: 2012

Journal: Heart Rhythm

Journal name in source: HEART RHYTHM

Journal acronym: HEART RHYTHM

Number in series: 10

Volume: 9

Issue: 10

First page : 1627

Last page: 1634

Number of pages: 8

ISSN: 1547-5271

DOI: https://doi.org/10.1016/j.hrthm.2012.06.008

Abstract

CONCLUSIONS In a genome-wide association study, we were not able to reliably identify genetic variants predisposing to ERP, presumably due to insufficient statistical power and phenotype heterogeneity. The reported heritability of ERP warrants continued investigation in larger well-phenotyped populations.