A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Biodistribution and radiation dosimetry of [C-11]choline: a comparison between rat and human data
Tekijät: Tolvanen T, Yli-Kerttula T, Ujula T, Autio A, Lehikoinen P, Minn H, Roivainen A
Kustantaja: SPRINGER
Julkaisuvuosi: 2010
Journal: European Journal of Nuclear Medicine and Molecular Imaging
Tietokannassa oleva lehden nimi: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Lehden akronyymi: EUR J NUCL MED MOL I
Numero sarjassa: 5
Vuosikerta: 37
Numero: 5
Aloitussivu: 874
Lopetussivu: 883
Sivujen määrä: 10
ISSN: 1619-7070
DOI: https://doi.org/10.1007/s00259-009-1346-z
Tiivistelmä
The absorbed radiation doses after administration of 460 MBq of [C-11]choline were low. Except for the pancreas, biodistribution in the rat was in accordance with that in humans, but rat data may underestimate the effective dose, suggesting that clinical measurements are needed for a more detailed estimation. The observed effective doses suggest the feasibility of [C-11]choline PET for human studies.
The absorbed radiation doses after administration of 460 MBq of [C-11]choline were low. Except for the pancreas, biodistribution in the rat was in accordance with that in humans, but rat data may underestimate the effective dose, suggesting that clinical measurements are needed for a more detailed estimation. The observed effective doses suggest the feasibility of [C-11]choline PET for human studies.
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