A1 Refereed original research article in a scientific journal
Biodistribution and radiation dosimetry of [C-11]choline: a comparison between rat and human data
Authors: Tolvanen T, Yli-Kerttula T, Ujula T, Autio A, Lehikoinen P, Minn H, Roivainen A
Publisher: SPRINGER
Publication year: 2010
Journal: European Journal of Nuclear Medicine and Molecular Imaging
Journal name in source: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Journal acronym: EUR J NUCL MED MOL I
Number in series: 5
Volume: 37
Issue: 5
First page : 874
Last page: 883
Number of pages: 10
ISSN: 1619-7070
DOI: https://doi.org/10.1007/s00259-009-1346-z(external)
Abstract
The absorbed radiation doses after administration of 460 MBq of [C-11]choline were low. Except for the pancreas, biodistribution in the rat was in accordance with that in humans, but rat data may underestimate the effective dose, suggesting that clinical measurements are needed for a more detailed estimation. The observed effective doses suggest the feasibility of [C-11]choline PET for human studies.
The absorbed radiation doses after administration of 460 MBq of [C-11]choline were low. Except for the pancreas, biodistribution in the rat was in accordance with that in humans, but rat data may underestimate the effective dose, suggesting that clinical measurements are needed for a more detailed estimation. The observed effective doses suggest the feasibility of [C-11]choline PET for human studies.
UTU Research Portal