Jussi Lehto - UTU Research Portal

Jussi Lehto

InFLAMES Flagship (Faculty of Medicine)

juleht@utu.fi

Publications

Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis2025
- Nature MedicineSpringerPlus
Klotz, Luisa; Smolders, Joost; Lehto, Jussi; Matilainen, Markus; Lütje, Lukas; Buchholz, Luzia; Albrecht, Stefanie; Walter, Carolin; Varghese, Julian; Wiendl, Heinz; Nylund, Marjo; Thomas, Christian; Gardberg, Maria; van den Bosch, Aletta M. R.; Airas, Laura; Huitinga, Inge; Kuhlmann, Tanja
(A1 Refereed original research article in a scientific journal)
Longitudinal accumulation of glial activation measured by TSPO-PET predicts later brain atrophy in multiple sclerosisApplication of cross-species PET imaging to assess neurotransmitter release in brain (2025)
- Journal of Neuroinflammation
Nylund, Marjo; Lehto, Jussi; Matilainen, Markus; Rajander, Johan; Wahlroos, Saara; Sucksdorff, Marcus; Kuhlmann, Tanja; Airas, Laura
(A1 Refereed original research article in a scientific journal)
Plasma CHI3L1 associates with brain volume loss and glial activation in multiple sclerosis (2025)
- Journal of Neurology, Neurosurgery and Psychiatry
Ahola, Venla; Saraste, Maija; Nylund, Marjo; Matilainen, Markus; Luoma, Amelie; Vuorimaa, Anna; Lehto, Jussi; Laaksonen, Sini; Brockmann, Eeva-Christine; Kuhle, Jens; Leppert, David; Soukka, Tero; Lamminmäki, Urpo; Airas, Laura
(A1 Refereed original research article in a scientific journal)
Imaging of a2C-adrenoceptors in the living brain: a method to monitor noradrenaline release?2025
- Neurology, Neuroimmunology and NeuroinflammationSynapse
Luoma, Amelie; Matilainen, Markus; Tuisku, Jouni Mikael; Aarnio, Richard; Nikkilä, Taru; Laaksonen, Sini; Koivumäki, Mikko; Honkonen, Eveliina; Nylund, Marjo; Wahlroos, Saara; Solin, Olof; Chen, Ming-Kai; Toyonaga, Takuya; Lehto, Jussi; Snellman, Anniina; Rinne, Juha O.; Airas, Laura M.
(A1 Refereed original research article in a scientific journal)
(2024)
- EJNMMI Research
Lehto, Jussi; Aarnio, Richard; Tuisku, Jouni; Sucksdorff, Marcus; Koivumäki, Esa Mikko; Nylund, Marjo; Helin, Semi; Rajander, Johan; Danon, Jonathan; Gilchrist, Jayson; Kassiou, Michael; Oikonen, Vesa; Airas, Laura
(A1 Refereed original research article in a scientific journal)
(2024)
- Multiple Sclerosis
Luoma, Amelie; Matilainen, Markus; Tuisku, Jouni; Aarnio, Richard; Nikkila, Taru; Laaksonen, Sini; Koivumaki, Mikko; Honkonen, Eveliina; Nylund, Marjo; Wahlroos, Saara; Toyonaga, Takuya; Chen, Ming-Kai; Lehto, Jussi; Snellman, Anniina; Rinne, Juha; Airas, Laura
(Abstract)
TSPO-PET-measurable microglial activity remains unaltered in cladribine-treated RRMS patientsValidation of [11C]ORM-13070 as a PET tracer for alpha2c-adrenoceptors in the human brain (2024)
- Multiple Sclerosis
Rajalehto, Olli; Saraste, Maija; Matilainen, Markus; Nylund, Marjo; Honkonen, Eveliina; Lehto, Jussi; Airas, Laura
(Poster)
Longitudinal stability of progression-related microglial activity during teriflunomide treatment in patients with multiple sclerosis (2023)
- European Journal of NeurologyJournal of NeurologyPsychopharmacology
Lehto Jussi, Nylund Marjo, Matilainen Markus, Sucksdorff Marcus, Vuorimaa Anna, Rajander Johan, Wahlroos Saara, Hariri Parisa, Laura Airas
(A1 Refereed original research article in a scientific journal)
PET-measurable innate immune cell activation reduction in chronic active lesions in PPMS brain after rituximab treatment: a case report (2023)
Lehto Jussi, Sucksdorff Marcus, Nylund Marjo, Raitanen Roope, Matilainen Markus, Airas Laura
(B1 Non-refereed article in a scientific journal)
The effect of an apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers on brachial artery flow-mediated vasodilatory function in volunteers with elevated blood pressure (2017)
- Nutrition Journal
Saarenhovi M, Salo P, Scheinin M, Lehto J, Lovro Z, Tiihonen K, Lehtinen MJ, Junnila J, Hasselwander O, Tarpila A, Raitakari OTA1 Refereed original research article in a scientific journal
Detecting a dexmedetomidine-evoked reduction of noradrenaline release in the human brain with the α2C-adrenoceptor PET ligand [11C]ORM-13070The alpha2C-adrenoceptor as a neuropsychiatric drug tar-get - PET studies in human subjects (2016)
- Synapse
Lehto J, Scheinin A, Johansson J, Marjamäki P, Arponen E, Scheinin H, Scheinin M
(A1 Refereed original research article in a scientific journal)
(2015)
- Psychopharmacology
Finnema SJ, Scheinin M, Shahid M, Lehto J, Borroni E, Bang-Andersen B, Sallinen J, Wong E, Farde L, Halldin C, Grimwood S
(A2 Refereed review article in a scientific journal )
(2015)
Scheinin M, Lehto J, Johansson J, Luoto P, Arponen E, Vuorilehto L, Scheinin H, Rouru J
(Other publication)
Sensitivity of [C-11]ORM-13070 to increased extracellular noradrenaline in the CNS - a PET study in human subjects (2015)
Lehto J, Johansson J, Vuorilehto L, Luoto P, Arponen E, Scheinin H, Rouru J, Scheinin M
(A1 Refereed original research article in a scientific journal)
Test-retest reliability of (11)C-ORM-13070 in PET imaging of α2C-adrenoceptors in vivo in the human brain (2015)
- European Journal of Nuclear Medicine and Molecular Imaging
Jussi Lehto, Jere R. Virta, Vesa Oikonen, Anne Roivainen, Pauliina Luoto, Eveliina Arponen, Semi Helin, Johanna Hietamäki, Aila Holopainen, Marita Kailajärvi, Juha M. Peltonen, Juha Rouru, Jukka Sallinen, Kirsi Virtanen, Iina Volanen, Mika Scheinin, Juha O. Rinne
(A1 Refereed original research article in a scientific journal)
(2015) Lehto Jussi
(G5 Article dissertation )
(2015)
Jussi Lehto, Mika M. Hirvonen, Jarkko Johansson, Jukka Kemppainen, Pauliina Luoto, Tarja Naukkarinen, Vesa Oikonen, Eveliina Arponen, Juha Rouru, Jukka Sallinen, Harry Scheinin, Lauri Vuorilehto, Sjoerd J. Finnema, Christer Halldin, Juha O. Rinne, Mika Scheinin
(A1 Refereed original research article in a scientific journal)