Otto Kauko - UTU Research Portal - UTU Research Portal

Otto Kauko

- Senior Research Fellow,
Turku Bioscience Centre (Independent units)

otkauko@utu.fi

Improved breast milk proteome coverage by DIA based LC-MS/MS method (2024)
- Proteomics
Viitaharju, Jenni; Polari, Lauri; Kauko, Otto; Merilahti, Johannes; Rokka, Anne; Toivola, Diana M.; Laitinen, Kirsi
A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites (2023)
- Nature Biotechnology
Pihlajamaa Päivi, Kauko Otto, Sahu Biswajyoti, Kivioja Teemu, Taipale Jussi
PP2A-based triple-strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells (2023)
- Molecular Oncology
Denisova Oxana V., Merisaari Joni, Huhtaniemi Riikka, Qiao Xi, Yetukuri Laxman, Jumppanen Mikael, Kaur Amanpreet, Pääkkönen Mirva, von Schantz-Fant Carina, Ohlmeyer Michael, Wennerberg Krister, Kauko Otto, Koch Raphael, Aittokallio Tero, Taipale Mikko, Westermarck Jukka
PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers (2023)
- Molecular Oncology
Aakula Anna, Isomursu Aleksi, Rupp Christian, Erickson Andrew, Gupta Nikhil, Kauko Otto, Shah Pragya, Padzik Artur, Pokharel Yuba Raj, Kaur Amanpreet, Li Song-Ping, Trotman Lloyd, Taimen Pekka, Rannikko Antti, Lammerding Jan, Paatero Ilkka, Mirtti Tuomas, Ivaska Johanna, Westermarck Jukka
Protein phosphatase PP2A-based triple-strike therapy for medulloblastoma (2023)
- Molecular Oncology
Denisova O., Huhtaniemi R., Merisaari J., Qiao X., Pääkkönen M., Ohlmeyer M., Kauko O., Westermarck J.
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A (2023)
- Nature Communications
Pavic Karolina, Gupta Nikhil, Omella Judit Domènech, Derua Rita, Aakula Anna, Huhtaniemi Riikka, Määttä Juha A, Höfflin Nico, Okkeri Juha, Wang Zhizhi, Kauko Otto, Varjus Roosa, Honkanen Henrik, Abankwa Daniel, Köhn Maja, Hytönen Vesa P, Xu Wenqing, Nilsson Jakob, Page Rebecca, Janssens Veerle, Leitner Alexander, Westermarck Jukka
Arginine Methyltransferase PRMT7 Deregulates Expression of RUNX1 Target Genes in T-Cell Acute Lymphoblastic Leukemia (2022)
- Cancers
Oksa Laura, Mäkinen Artturi, Nikkilä Atte, Hyvärinen Noora, Laukkanen Saara, Rokka Anne, Haapaniemi Pekka, Seki Masafumi, Takita Junko, Kauko Otto, Heinäniemi Merja, Lohi Olli
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer (2021)
- Cell
Vervoort Stephin J, Welsh Sarah A, Devlin Jennifer R, Barbieri Elisa, Knight Deborah A, Offley Sarah, Bjelosevic Stefan, Costacurta Matteo, Todorovski Izabela, Kearney Conor J, Sandow Jarrod J, Fan Zheng, Blyth Benjamin, McLeod Victoria, Vissers Joseph HA, Pavic Karolina, Martin Ben P, Gregory Gareth, Demosthenous Elena, Zethoven Magnus, Kong Isabella Y, Hawkins Edwin D, Hogg Simon J, Kelly Madison J, Newbold Andrea, Simpson Kaylene J, Kauko Otto, Harvey Kieran F, Ohlmeyer Michael, Westermarck Jukka, Gray Nathanael, Gardini Alessandro, Johnstone Ricky W
Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1 (2020)
- Journal of Biological Chemistry
Kauko O, Imanishi SY, Kulesskiy E, Yetukuri L, Laajala TD, Sharma M, Pavic K, Aakula A, Rupp C, Jumppanen M, Haapaniemi P, Ruan L, Yadav B, Suni V, Varila T, Reimand J, Corthals GL, Aittokallio T, Wennerberg K, Westermarck J
Arpp19 Promotes Myc and Cip2a Expression and Associates with Patient Relapse in Acute Myeloid Leukemia (2019)
- Cancers
Mäkelä E, Löyttyniemi E, Salmenniemi U, Kauko O, Varila T, Kairisto V, Itälä-Remes M, Westermarck J
Non-genomic mechanisms of protein phosphatase 2A (PP2A) regulation in cancer (2018)
- International Journal of Biochemistry and Cell Biology
Otto Kauko, Jukka Westermarck
Phosphonormalizer: an R package for normalization of MS-based label-free phosphoproteomics (2018)
- Bioinformatics
Sohrab Saraei, Tomi Suomi, Otto Kauko, Laura L. Elo
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells (2018)
- Science Translational Medicine
Otto Kauko, Caitlin M. O’Connor, Evgeny Kulesskiy, Jaya Sangodkar, Anna Aakula, Sudeh Izadmehr, Laxman Yetukuri, Bhagwan Yadav, Artur Padzik, Teemu Daniel Laajala, Pekka Haapaniemi, Majid Momeny, Taru Varila, Michael Ohlmeyer, Tero Aittokallio, Krister Wennerberg, Goutham Narla, Jukka Westermarck
A Systems Biology Analysis of PP2A Functions in Cancer Cells (2017) Kauko Otto
Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56 (2017)
- EMBO Reports
Jiao Wang, Juha Okkeri, Karolina Pavic, Zhizhi Wang, Otto Kauko, Tuuli Halonen, Grzegorz Sarek, Päivi M Ojala, Zihe Rao, Wenqing Xu, Jukka Westermarck
PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression (2017)
- Developmental Cell
Ying Liu, Jaakko Mattila, Sami Ventelä, Leena Yadav, Wei Zhang, Nicole Lamichane, Jari Sundström, Otto Kauko, Reidar Grénman, Markku Varjosalo, Jukka Westermarck, Ville Hietakangas
Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling (2015)
- Scientific Reports
Otto Kauko, Teemu Daniel Laajala, Mikael Jumppanen, Petteri Hintsanen, Veronika Suni, Pekka Haapaniemi, Garry Corthals, Tero Aittokallio, Jukka Westermarck, Susumu Y. Imanishi
Protein phosphatase 2A activity is a major determinant of therapy response in cancer cells (2015)
- Cancer Research
Kauko O, Imanishi S, Kaur A, Laajala D, Kulesskiy E, Jumppanen M, Corthals G, Aittokallio T, Wennerberg K, Westermarck J
Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells (2013)
- Cancer Research
Khanna A, Kauko O, Böckelman C, Laine A, Schreck I, Partanen J, Szwajda A, Bormann S, Bilgen T, Helenius M, Pokharel Y, Pimanda J, Russel M, Haglund C, Cole K, Klefström J, Aittokallio T, Weiss C, Ristimäki A, Visakorpi T, Westermarck J
CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypes (2012)
- Oncogene
Niemelä M, Kauko O, Sihto H, Mpindi J-P, Nicorici D, Pernilä P, Kallioniemi O-P, Joensuu H, Hautaniemi S, Westermarck J